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KMID : 0043319960190030197
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Archives of Pharmacal Research
1996 Volume.19 No. 3 p.197 ~ p.200
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6-[(N-2,3-Dichlorophenyl)amino]-7-Chloro-5,8-Quinoline-dione Treatment of Candidiasis in Normal Mice
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Ryu Chung-Kyu
Kim Dong-Hyun
Lee In-Kyung
Kim Sung-Hee
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Abstract
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6-[(N-2,3-Dichlorophenyl)aminol-7-chloro-5,8-quinolinedione (RCK1 1) was tested for in vivo antifungal activities in the treatment of systemic infection with Canclicla albicans in normal mice compared with ketoconazole. The therapeutic potential of RCK11 had been assessed by evaluating their activities (survival rates) against systemic infections in normal mice. of intraperitoneally administered RCK11 was but that of ketoconazole had respectively. When RCK11 was administered intravenously at the (0.10 mg/kg), the colony counts of Canoliola albicans in the liver after 7 days and 14 days were reduced as likely as ketoconazole at the (8.00 mg/kg), and the better survival rates than ketoconazole were achieved after 14 days. The results suggest that RCK11 may be a potent antifungal agent.
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KEYWORD
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6-[(N-2, 3-dichloropheny)-amino-7-chloro-5, 8-quinolinedione, Candida alicans, Candidiasis, in vivo antifungal activity
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